Advanced Pharmaceutics: Physicochemical Principles by Cherng-ju Kim

By Cherng-ju Kim

Discussing a finished variety of issues, complex Pharmaceutics: Physicochemical rules studies all points of actual pharmacy. The publication explains the fundamental, mechanistic, and quantitative interpretation talents had to remedy actual pharmacy similar difficulties. the writer offers a powerful primary historical past and generally covers thermodynamics, ionic equilibria, ideas and distribution, floor chemistry and colloids, kinetics, diffusion, and polymer technology. He outlines the most recent study on diffusion via a membrane and using polymers in dosage forms.

Packed with formulae and versions, the booklet demonstrates the improvement of every after which describes using these versions for various formula occasions. The author's precise rationalization of the evolution of the formulae presents a transparent knowing of whilst and the way they're used. This bottom-up process delineates the evolution of the formulae and provides a transparent figuring out of whilst and the way they need to be used. The publication offers an in-depth evaluation and research of dosage shape layout standards so you might speedily enforce on your daily paintings.

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What is the vapor pressure at 85°C? 8 kcal/mol. , E, H, A, and G) and temperature, pressure, and volume. 96) are the four basic equations of thermodynamics from which partial derivatives can be derived in terms of the temperature, pressure, and volume. fm Page 29 Friday, January 30, 2004 6:15 PM very useful in obtaining quantities not easily determined by other methods. Readers interested in this subject should consult the physical chemistry books listed at the end of this chapter. However, two important applications of the thermodynamic relationships are discussed here: internal pressure and the Gibbs–Helmholtz equation.

Fm Page 19 Friday, January 30, 2004 6:15 PM though the system returns to the initial state. The thermodynamic efficiency of the Carnot cycle is defined as the net work done by the system divided by the heat absorbed. 56) implies that the efficiency depends on the two operating temperatures of the engine. The smaller the numerator (temperature difference), the less heat absorbed is converted to work. If the lower temperature is at absolute zero, the efficiency becomes 100%. The engine described is not of interest to pharmaceutical scientists but important to engineers and others who deal with heat engines or refrigerators.

7. Calculate the entropy change when hot water (80°C) comes in contact with cold water (5°C). The heat capacity of water at constant pressure is 75 J/K/mol. Heat is not lost to the surroundings during this operation. 8. Calculate the free energy change of hydrolysis of glycylglycine at 25°C and 1 atm in a dilute aqueous solution at 37°C and 1 atm: H 3 N + CH 2 CONHCH 2 COO − (aq) + H 2 O(l)  → 2H 3 N + CH 2 COO − (aq) 9. Derive the equation  ∂S   ∂V     = −  ∂T  P  ∂P  T 10. Calculate the equilibrium constant for the following reaction at 25°C: CH 3COCOOH(l)  → CH 3COH(g) + CO 2 (g) 11.

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