Antidepressants, Antipsychotics, Anxiolytics: From Chemistry by Helmut Buschmann, J?rg Holenz, Antonio Párraga, Antoni

By Helmut Buschmann, J?rg Holenz, Antonio Párraga, Antoni Torrens, José Miguel Vela, José Luis D?az

Antidepressants and similar psychiatric medicines are crucial prescribed drugs around the globe, accounting for a marketplace quantity of 20 billion US$ consistent with 12 months. This instruction manual offers a whole and exact review of all at the moment to be had psychiatric medicinal drugs, protecting greater than 250 diverse compounds.
specific good points include:
* an important details at the chemistry, pharmacology and healing use of a given drug
* a distinct structure with margin notes and compound buildings bearing in mind speedy and straightforward entry to the specified information
Written by means of drug builders from the pharmaceutical undefined, novel medicines at present below improvement and new equipment of therapy are indexed facet via facet with classical medicinal drugs, permitting a right away comparability of conventional and leading edge healing approaches.Content:
Chapter 1.1 Introductory and easy elements (pages 2–50): Luz Romero, Ana Montero, Begona Fernandez and Jose M. Vela
Chapter 1.2 Clinics (pages 51–110): Rosario Perez?Egea, Victor Perez, Dolors Puigdemont and Enric Alvarez
Chapter 1.3 Pharmacology (pages 111–140): Begona Fernandez, Luz Romero and Ana Montero
Chapter 1.4 Experimental examine (pages 141–172): Ana Montero, Begona Fernandez and Luz Romero
Chapter 1.5 Chemistry (pages 173–296): Jorg Holenz, Jose Luis Diaz and Helmut Buschmann
Chapter 2.1 Introductory and uncomplicated elements (pages 298–334): Francesc Artigas
Chapter 2.2 Clinics (pages 335–388): Salvador Ros and Francisco Javier Arranz
Chapter 2.3 Pharmacology (pages 389–448): Analia Bortolozzi, Llorenc Diaz?Mataix and Francesc Artigas
Chapter 2.4 Experimental learn (pages 449–489): Pau Celada, Anna Castane, Albert Adell and Francesc Artigas
Chapter 2.5 Chemistry (pages 491–616): Antonio Parraga, Jorg Holenz and Helmut Buschmann
Chapter 3.1 Introductory and simple points (pages 618–880): Francisca Lopez?Rios, Serafin Gomez?Martin and Antonio Molina?Moreno
Chapter 3.2 Clinics (pages 881–894): Blanca Gutierrez and Jorge Cervilla
Chapter 3.3 Pharmacology (pages 895–922): Jose Manuel Baeyens
Chapter 3.4 Experimental learn (pages 923–949): Enrique Portillo and Jose M. Vela
Chapter 3.5 Chemistry (pages 951–1087): Monica Garca?Loapez, Susana Yenes, Helmut Buschmann and Antoni Torrens
Chapter 4.1 Introductory and simple elements (pages 1090–1103): Javier Burgueno, Rafael Franco and Francisco Ciruela
Chapter 4.2 Clinics (pages 1105–1154): Francisco Javier Arranz and Salvador Ros
Chapter 4.3 Pharmacology (pages 1155–1182): Francisco Ciruela, Rafael Franco and Javier Burgueno
Chapter 4.4 Chemistry (pages 1183–1196): Jorg Holenz, Jose Luis Diaz and Helmut Buschmann

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Extra resources for Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application

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An integrative approach to depression: genetic and environmental factors (adapted from Wong and Licinio, 2001). , 1994). Allelic variations in the serotonin transporter (5-HTT) gene are of great interest in depression. A polymorphism in the 5' promoter region consisting of a short (s) and a long (l) allele with the s-allele being associated with decreased 5HT transmembrane transport and reduced transporter mRNA has been described. , 2001). , 2003). , 2002). , 2004). These individuals respond much faster to antidepressants and have a higher recurrence of depressive episodes than individuals without this mutation.

Suicide remains one of the most common and unavoidable outcomes of depression and is now the eighth leading cause of death in the United States. Several lines of evidence indicate an important contribution of depression to medical morbidity. Depressive disorders often co-occur with anxiety disorders, bulimia, anorexia and substance abuse. , 2000) and depressed patients have an increased risk of premature death compared with control subjects (Harris and Barraclough, 1998). To date, no single antidepressant drug is effective in all patients treated, probably due to the heterogeneity of the disease and to individual differences in the response to the agents used.

Target identification ldentifying a molecule (often a protein) that is instrumental to a disease process (though not necessarily directly involved), with the intention of finding a way to regulate that molecule's activity for therapeutic purposes. Target validation Crucial step in the drug discovery process. Following the identification of a potential disease target, target validation verifies that a drug that specifically acts on the target can have a significant therapeutic benefit in the treatment of a given disease.

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