By Hansen, Steen; Pedersen-Bjergaard, Stig
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Extra resources for Bioanalysis of pharmaceuticals : sample preparation, separation techniques and mass spectrometry
2% is present. 5, the peaks are considered to be fully separated. However, this is only true when the peaks in question are of similar heights. If large differences in peak heights are present, the minor peak may be compromised by a larger overlap from the major peak. 4), given as the ratio A/B. An increase in resolution may be achieved in two different ways: (i) by increasing the difference in retention (this is an increase in selectivity, ????; see below), or (ii) by achieving narrower peaks (this is an increase in efficiency, N).
This means that at certain pH values, they both have a positive and negative charge, but overall they are neutral. 8), all amino acids (except glycine) are chiral. As building blocks for peptides and proteins, mainly L-amino acids are used. 8 shows the general structure of an amino acid, its chiral C-atom, as well as their charge profile in relation to pH. There are, in total, 20 different naturally existing amino acids present in peptides and proteins. These differences are due to variations in the side chains (R) and can be categorized as polar, nonpolar, basic, acidic, aliphatic, and aromatic.
One very important issue in the collection and storage of biosamples is to use labels and text that are waterproof. Otherwise, the information on the vial stored in a freezer may be lost. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry, First Edition. Steen Honoré Hansen and Stig Pedersen-Bjergaard. © 2015 John Wiley & Sons, Ltd. Published 2015 by John Wiley & Sons, Ltd. 24 Bioanalysis of Pharmaceuticals The best type of sample to use in a given situation depends on the question to be answered.