Biomolecular Interfaces: Interactions, Functions and Drug by Ariel Fernández Stigliano

By Ariel Fernández Stigliano

The booklet specializes in the aqueous interface of biomolecules, an essential but neglected quarter of biophysical examine. such a lot organic phenomena can't be totally understood on the molecular point with out contemplating interfacial behavior.

The writer offers conceptual advances in molecular biophysics that bring in the arrival of a brand new self-discipline, epistructural biology, headquartered at the interactions of water and bio molecular buildings around the interface. the writer introduces robust theoretical and computational assets as a way to tackle basic subject matters comparable to protein folding, the physico-chemical foundation of enzyme catalysis and protein institutions. at the foundation of this knowledge, a multi-disciplinary process is used to engineer healing medications and to permit substantial advances in particular molecular drugs. This booklet could be of curiosity to scientists, scholars and practitioners within the fields of chemistry, biophysics and biomedical engineering.

Show description

Read or Download Biomolecular Interfaces: Interactions, Functions and Drug Design PDF

Best pharmacy books

Advanced Computer-Assisted Techniques in Drug Discovery

Using strong pcs has revolutionized molecular layout and drug discovery. completely researched and well-structured, this complete instruction manual covers powerful and effective thoughts in 3D-QSAR and complex statistical research. The emphasis is on exhibiting clients tips on how to practice those tools and steer clear of high priced and time-consuming methodical mistakes.

Annual Reports in Medicinal Chemistry, 4

ANNUAL studies IN MED CHEMISTRY V4 PPR.

Non-Biological Complex Drugs: The Science and the Regulatory Landscape

The increase of bio- and nano-technology within the final many years has resulted in the emergence of a brand new and distinct form of drugs referred to as non-biological advanced medicines (NBCDs). This e-book illustrates the demanding situations linked to NBCD improvement, in addition to the complexity of assessing the consequences of producing adjustments on innovator and follow-on batches of NBCDs.

Control and Prediction of Solid-State of Pharmaceuticals : Experimental and Computational Approaches

This thesis investigates various experimental and computational methods for the invention of sturdy varieties. moreover, we achieve, as readers, a greater knowing of the foremost components underpinning solid-structure and variety. a massive a part of this thesis highlights experimental paintings performed on structurally very related compounds.

Additional info for Biomolecular Interfaces: Interactions, Functions and Drug Design

Sample text

Thus, the thermal denaturation free energy change, ΔG, under reducing conditions and comparable temperatures [47, 48] was obtained for monomeric uncomplexed PDB-reported proteins with disulfide bonds and lacking prosthetic groups or ion coordination. 72, Fig. 10) between the deviation from the balance equation, measured as Y – (5X + 20), and the thermal denaturation free energy (ΔG). This tight anticorrelation provides a thermodynamic validation of the balance equation. 92 1RHB 1K5A a SCOP structural classification of proteins (Murzin et al.

Fernández A (2003) What caliber pore is like a pipe? Nanotubes as modulators of ion gradients. J Chem Phys 119:5315–5319 41. Despa F, Fernández A, Berry RS (2004) Dielectric modulation of biological water. Phys Rev Lett 93:228104 42. Demetri G (2002) Efficacy and safety of imatinib mesyalte in advanced gastrointestinal stromal tumors. N Engl J Med 347:472–480 43. Fernández A, Sanguino A, Peng Z, Ozturk E, Chen J, Crespo A, Wulf S, Shavrin A, Qin C, Ma J, Trent J, Lin Y, Han HD, Mangala LS, Bankson JA, Gelovani J, Samarel A, Bornmann References 44.

Pietrosemoli N, Crespo A, Fernández A (2007) Dehydration propensity of order-disorder intermediate regions in soluble proteins. J Proteome Res 6:3519–3526 29. Fernández A, Scott R (2003) Dehydron: a structure-encoded signal for protein interactions. Biophys J 85:1914–1928 30. Avbelj F, Baldwin RL (2003) Role of backbone solvation and electrostatics in generating preferred peptide backbone conformations: distributions of phi. Proc Natl Acad Sci USA 100:5742–5747 31. Krantz BA, Moran LB, Kentsis A, Sosnick TR (2000) D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding.

Download PDF sample

Rated 4.55 of 5 – based on 35 votes

Categories: Pharmacy