By György Keserü, David C. Swinney
This functional reference for medicinal and pharmaceutical chemists combines the theoretical historical past with smooth tools in addition to functions from contemporary lead discovering and optimization tasks.
Divided into components at the thermodynamics and kinetics of drug-receptor interplay, the textual content presents the conceptual and methodological foundation for characterizing binding mechanisms for medications and different bioactive molecules. It covers all at present used tools, from experimental ways, akin to ITC or SPR, correct as much as the newest computational tools. Case stories of real-life lead or drug improvement initiatives also are incorporated so readers can practice the equipment realized to their very own tasks. eventually, the advantages of a radical binding mode research for any drug improvement venture are summarized in an outlook bankruptcy written by means of the editors.