By Hari G. Garg, Robert J. Linhardt, Charles A. Hales
The chemistry, biochemistry and pharmacology of heparin and heparan sulfate were and remain a tremendous medical venture - heparin and its spinoff stay very important medicines in medical perform. Chemistry and Biology of Heparin and Heparan Sulfate offers readers with an perception into the chemistry, biology and scientific purposes of heparin and heparan sulfate and examines their functionality in quite a few physiological and pathological stipulations. supplying a wealth of beneficial info, no different tome covers the variety of themes within the box. scholars, medical professionals, chemists, biochemists, and learn scientists will locate this ebook a useful resource for updating their present wisdom of advancements during this sector. * Comprehensively studies all elements of heparin and heparan sulfate learn* Uniquely describes the chemistry, biology and medical program of heparins and heparan sulfates in a single paintings* presents a useful resource of information of present advancements for chemists, biochemists, docs, researchers, scholars and practitioners
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Extra resources for Chemistry and Biology of Heparin and Heparan Sulfate
Heparan sulfate proteoglycans identified in Alzheimer's patients include perlecan, agrin, syndecan-1 through -3, and glypican-1. Perlecan expression is limited to senile plaques in the cortex but not cerebellum. The cortex is not the usual site for senile plaque formation (140). Based on the binding of perlecan to amyloid [3 protein and the amyloid precursor protein, it is possible that perlecan may play a role in amyloid fibril formation (141). Verbeek et al. (142) through immunohistochemical analysis showed that agrin is localized in senile plaques, neurofibrillary tangles, and cerebral blood vessels.
Structure and Active Domains of Heparin 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 23 Iacomini M, Casu B, Guerrini M, Naggi A, Pirola A, Torri G. "Linkage region" sequences of heparins and heparan sulfates: detection and quantification by nuclear magnetic resonance spectroscopy. Anal Biochem 1999; 274: 50-58. Hanhenberger R, Jakobson ,~M, Ansari A, Wehler T, Svahn CM, Lindahl U. Low-sulfated oligosaccharides derived from heparan sulfate inhibit normal angiogenesis. Glycobiology 1993; 3:567-573.
Active conformations of glycosaminoglycans. NMR determination of the conformation of heparin sequences complexed with antithrombin and with fibroblasts growth factors in solution. Semin Thromb Hemost 2002; 28:325-334. Hricovini M, Guerrini M, Bisio A, Torri G, Petitou M, Casu B. Conformation of heparin pentasaccharide bound to antithrombin III. Biochem J 2001; 359:265-272. Canales A, Angulo J, Ojeda R, Bruix M, Fayos R, Lozano R, Gim6nezGallego G, Martin-Lomas M, Nieto PM, Jim6nez-Barbero J. Conformational flexibility of a synthetic glycosaminoglycan bound to a fibroblast growth factor.
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